Day: June 20, 2024

Scientists argue over the origins of COVID-19 before U.S. Senate panel  Idaho State Journal

Nevada is years away from healing COVID wounds, report says  New York Post

Putin in Vietnam, seeking to strengthen ties in Southeast Asia while Russia’s isolation deepens  The Washington Post

Тело утонувшего накануне в Цхинвале подростка обнаружено спасательным отрядом в селе Пхвенис Горийского муниципалитета Грузии, сообщает МЧС Южной Осетии.

Стоимость поставок составила $27,8 млрд.

Уголовное дело заведено по факту возбуждения ненависти или уничижения человеческого достоинства.

How Russia is using nuclear power to win global influence  Financial Times

Sex differences have been observed in acute COVID-19 and Long COVID (LC) outcomes, with greater disease severity and mortality during acute infection in males and a greater proportion of females developing LC. We hypothesized that sex-specific immune dysregulation contributes to the pathogenesis of LC. To investigate the immunologic underpinnings of LC development and persistence, we used single-cell transcriptomics, single-cell proteomics, and plasma proteomics on blood samples obtained during acute SARS-CoV-2 infection and at 3 and 12 months post-infection in a cohort of 45 patients who either developed LC or recovered. Several sex-specific immune pathways were associated with LC. Specifically, males who would develop LC at 3 months had widespread increases in TGF-{beta} signaling during acute infection in proliferating NK cells. Females who would develop LC demonstrated increased expression of XIST, an RNA gene implicated in autoimmunity, and increased IL1 signaling in monocytes at 12 months post infection. Several immune features of LC were also conserved across sexes. Both males and females with LC had reduced co-stimulatory signaling from monocytes and broad upregulation of NF-{kappa}B transcription factors. In both sexes, those with persistent LC demonstrated increased LAG3, a marker of T cell exhaustion, reduced ETS1 transcription factor expression across lymphocyte subsets, and elevated intracellular IL-4 levels in T cell subsets, suggesting that ETS1 alterations may drive an aberrantly elevated Th2-like response in LC. Altogether, this study describes multiple innate and adaptive immune correlates of LC, some of which differ by sex, and offers insights toward the pursuit of tailored therapeutics.

CCHD working to reintroduce itself to community after COVID  Hopkinsville Kentucky New Era

На фоне нарастающей российской угрозы страны Балтии продолжают вооружаться и укреплять свою оборону. Таллинн закупает новое оружие.