Day: June 19, 2024

Kansas sues Pfizer over COVID-19 vaccine – FOX31 Denver  FOX 31 Denver

Ex-FBI director James Comey says ‘zero chance of an acquittal’ in Trump’s hush money trial  Yahoo News Canada

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DENIED: Judge Aileen Cannon Buries Pro-Trump AGs Gag Brief  Mediaite

Dana White: Trump is the most resilient human being I’ve ever met  Fox News

A US soldier detained in Russia on charges of theft and threats to kill his girlfriend was found guilty Wednesday and sentenced to nearly four years in a Russian penal colony.

FLiRT Variant Threatens Summer COVID Rise: Know the Symptoms!  Longview News-Journal

There’s a new subvariant of COVID circulating. Here’s what you need to know.  Denton Record Chronicle

Coronavirus-infected cells contain double-membrane vesicles (DMVs) that are key for viral RNA replication and transcription, perforated by hexameric pores connecting the vesicular lumen to the cytoplasm. How pores form and traverse two membranes, and how DMVs organize RNA synthesis, is unknown. Using structure prediction and functional assays, we show that the non-structural viral membrane protein nsp4 is the key DMV pore organizer, spanning the double membrane and forming most of the pore lining. Nsp4 interacts with nsp3 on the cytoplasmic side and with the viral replicase inside the DMV. Newly synthesized mRNAs exit the DMV into the cytoplasm, passing through a narrow ring of conserved nsp4 residues. Steric constraints imposed by the ring predict that modified nucleobases block mRNA transit, with broad spectrum anti-coronaviral activity.

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